Mouse models of peripheral metabolic disease
نویسندگان
چکیده
منابع مشابه
Mouse models of the metabolic syndrome.
The metabolic syndrome (MetS) is characterized by obesity concomitant with other metabolic abnormalities such as hypertriglyceridemia, reduced high-density lipoprotein levels, elevated blood pressure and raised fasting glucose levels. The precise definition of MetS, the relationships of its metabolic features, and what initiates it, are debated. However, obesity is on the rise worldwide, and it...
متن کامل[Metabolic syndrome and peripheral arterial disease].
The metabolic syndrome (MetS) is a constellation of metabolic risk factors closely linked to insulin resistance. At present, various definitions for MetS are used. According to the criteria described by of the Adults Treatment Panel III recently revised by the American Heart Association/National Heart, Lung, and Blood Institute (rATP III-MetS) the MetS is defined as an alteration in three or mo...
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Strong correlations have been made between high levels of blood cholesterol and the risk to suffer Alzheimer's disease (AD). The question arises on how a peripheral event contributes to a disease that so severely affects the integrity and function of the Central Nervous System. Hypercholesterolemia has been also associated to peripheral metabolic disorders like diabetes, obesity or atherosclero...
متن کاملMouse Models of Alzheimer's Disease.
Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than 40 million people worldwide and it is predicted to exponentially increase in the coming decades. Because no curative treatment exists, research on the pathophysiology of the disease, as well as the testing of new drugs, are mandatory. For these purposes, animal models constitute a valuable, although perfect...
متن کاملPeripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy.
Spinal and bulbar muscular atrophy (SBMA) is caused by the polyglutamine androgen receptor (polyQ-AR), a protein expressed by both lower motor neurons and skeletal muscle. Although viewed as a motor neuronopathy, data from patients and mouse models suggest that muscle contributes to disease pathogenesis. Here, we tested this hypothesis using AR113Q knockin and human bacterial artificial chromos...
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ژورنال
عنوان ژورنال: Best Practice & Research Clinical Endocrinology & Metabolism
سال: 2018
ISSN: 1521-690X
DOI: 10.1016/j.beem.2018.03.009